Brand  (β version)

PDB ID: 1RA6

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Ligands
Code Name Style Show Link
ACY Acetic acid PoSSuM
Non-standard Residues
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CAS S-(dimethylarsenic)cysteine
Glycosylation
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Structure summary

Code : 1RA6   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Poliovirus Polymerase Full Length Apo Structure
Release Data : 2004-08-17
Compound :
mol_id molecule chains synonym
1 Genome polyprotein A P3D
ec: 2.7.7.48
fragment: RNA-directed RNA polymerase (residue 1748-2208)
mutation: L446D, R455D
Source :
mol_id organism_scientific expression_system
1 Human poliovirus 1  (taxid:12081) Escherichia coli  (taxid:562)
strain: Mahoney
gene: 3D
expression_system_strain: BL21 (DE3) PLYSS
expression_system_vector_type: PLASMID
expression_system_plasmid: pKKT7E
Authors : Thompson, A.A., Peersen, O.B.
Keywords : NUCLEOTIDYLTRANSFERASE, POLIOVIRUS, 3D, RNA-DEPENDENT, POLYMERASE, N-TERMINUS, transferase
Exp. method : X-RAY DIFFRACTION ( 2.0 Å )
Citation :

Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase.

Thompson, A.A.,Peersen, O.B.
(2004)  Embo J.  23 : 3462 - 3471

PubMed: 15306852
DOI: 10.1038/sj.emboj.7600357

Reaction

Chain : A
UniProt : P03300 (POLG_POL1M)
Reaction: EC: Evidence:
Physiological Direction:
[RNA-directed RNA polymerase]
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 		2.7.7.48 PROSITE-ProRule:PRU00539
-
[Protease 2A]
Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein. 		3.4.22.29 PubMed:1649327
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[Protein 2C]
a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate 		3.6.1.15 PubMed:19520852, PubMed:30231078, PubMed:7730315, PubMed:8385138
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[Protease 3C]
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly. 		3.4.22.28 PROSITE-ProRule:PRU01222, PubMed:8097606
-