Brand  (β version)

PDB ID: 1R78

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Ligands
Code Name Style Show Link
FMD 4-((3r,4s,5r)-4-amino-3,5-dihydroxy-hex-1-ynyl)-5-fluoro-3-[1-(3-methoxy-1h-pyrrol-2-yl)-meth-(z)-ylidene]-1,3-dihydro-indol-2-one PoSSuM
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Structure summary

Code : 1R78   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : CDK2 complex with a 4-alkynyl oxindole inhibitor
Release Data : 2004-01-20
Compound :
mol_id molecule chains synonym
1 Cell division protein kinase 2 A p33 protein kinase
ec: 2.7.1.-
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: CDK2
expression_system_common: Fall armyworm
expression_system_cell_line: SF9
expression_system_vector_type: baculovirus
expression_system_vector: PBAC2
Authors : Luk, K.-C., Simcox, M.E., Schutt, A., Rowan, K., Thompson, T., Chen, Y., Kammlott, U., DePinto, W., Dunten, P., Dermatakis, A.
Keywords : cyclin dependent kinase, serine/threonine protein kinase, oxindole, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

A new series of potent oxindole inhibitors of CDK2

Luk, K.-C.,Simcox, M.E.,Schutt, A.  et al.
(2004)  Bioorg.Med.Chem.Lett.  14 : 913 - 917

PubMed: 15012993
DOI: 10.1016/j.bmcl.2003.12.009

Reaction

Chain : A
UniProt : P24941 (CDK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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