Brand  (β version)

PDB ID: 1R5C

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Ligands
Code Name Style Show Link
CPA 2'-deoxycytidine-2'-deoxyadenosine-3',5'-monophosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1R5C   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : X-ray structure of the complex of Bovine seminal ribonuclease swapping dimer with D(CpA)
Release Data : 2004-04-13
Compound :
mol_id molecule chains synonym
1 Ribonuclease, seminal A,B Seminal RNase, S-RNase, Ribonuclease BS-1
ec: 3.1.27.5
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Cattle
Authors : Merlino, A., Vitagliano, L., Sica, F., Zagari, A., Mazzarella, L.
Keywords : ribonucleases, protein dynamics, protein structure-function, ligand binding, population shift, 3D domain swapping, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.1 Å )
Citation :

Population shift vs induced fit: The case of bovine seminal ribonuclease swapping dimer

Merlino, A.,Vitagliano, L.,Sica, F.  et al.
(2004)  Biopolymers  73 : 689 - 695

PubMed: 15048772
DOI: 10.1002/bip.20016

BOVINE SEMINAL RIBONUCLEASE: STRUCTURE AT 1.9 A RESOLUTION

Mazzarella, L.,Capasso, S.,Demasi, D.  et al.
(1993)  Acta Crystallogr.,Sect.D  49 : 389 - 402

DOI: 10.1107/S0907444993003403

Binding of a Substrate Analog to a Domain Swapping Protein: X-Ray Structure of the Complex of Bovine Seminal Ribonuclease with Uridylyl(2'-5')Adenosine

Vitagliano, L.,Adinolfi, S.,Riccio, A.  et al.
(1998)  Protein Sci.  7 : 1691 - 1699

Cosolute Effect on Crystallization of Two Dinucleotide Complexes of Bovine Seminal Ribonuclease from Concentrated Salt Solutions

Sica, F.,Adinolfi, S.,Vitagliano, L.  et al.
(1996)  J.Cryst.Growth  168 : 192 - 197

DOI: 10.1016/0022-0248(96)00354-5

A potential allosteric subsite generated by domain swapping in bovine seminal ribonuclease

VITAGLIANO, L.,Adinolfi, S.,Sica, F.  et al.
(1999)  J.Mol.Biol.  293 : 569 - 577

DOI: 10.1006/jmbi.1999.3158

Crystallization of Multiple Forms of Bovine Seminal Ribonuclease: the liganded and Unliganded State


(1999)  J.Cryst.Growth  196 : 305 - 312

Reaction

Chain : A, B
UniProt : P00669 (RNS_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
an [RNA] containing cytidine + H2O = an [RNA]-3'-cytidine-3'- phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA]. 4.6.1.18 PubMed:4664228
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an [RNA] containing uridine + H2O = an [RNA]-3'-uridine-3'- phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA]. 4.6.1.18 PubMed:4664228
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