Brand  (β version)

PDB ID: 1R3Y

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Ligands
Code Name Style Show Link
CP3 Coproporphyrinogen III PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1R3Y   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Uroporphyrinogen Decarboxylase in complex with coproporphyrinogen-III
Release Data : 2003-12-09
Compound :
mol_id molecule chains synonym
1 Uroporphyrinogen Decarboxylase A URO-D; UPD
ec: 4.1.1.37
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
expression_system_vector_type: plasmid
Authors : Phillips, J.D., Whitby, F.G., Kushner, J.P., Hill, C.P.
Keywords : uroporphyrinogen decarboxylase coproporphyrinogen; X-ray crystallography, LYASE
Exp. method : X-RAY DIFFRACTION ( 1.755 Å )
Citation :

Structural basis for tetrapyrrole coordination by uroporphyrinogen decarboxylase

Phillips, J.D.,Whitby, F.G.,Kushner, J.P.  et al.
(2003)  Embo J.  22 : 6225 - 6233

PubMed: 14633982
DOI: 10.1093/emboj/cdg606

Reaction

Chain : A
UniProt : P06132 (DCUP_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III 4.1.1.37 PubMed:11069625, PubMed:14633982, PubMed:18004775, PubMed:21668429
left-to-right PubMed:11069625, PubMed:14633982, PubMed:21668429
4 H(+) + uroporphyrinogen I = 4 CO2 + coproporphyrinogen I - PubMed:11719352, PubMed:14633982, PubMed:21668429
left-to-right