Het-PDB Navi2 (PDB: 1QZR)

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Ligands
Code	Name	Link
ANP	Phosphoaminophosphonic acid-adenylate ester	PoSSuM
CDX	(S)-4,4'-(1-methyl-1,2-ethanediyl)bis-2,6-piperazinedione	PoSSuM
MG	Magnesium ion	PoSSuM

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Download interaction data: 1QZR

Code :

1QZR PDBj RCSB PDB PDBe

Header :

ISOMERASE

Title :

CRYSTAL STRUCTURE OF THE ATPASE REGION OF SACCHAROMYCES CEREVISIAE TOPOISOMERASE II BOUND TO ICRF-187 (DEXRAZOXANE)

Release Data :

2003-09-30

Compound :

mol_id	molecule	chains
1	DNA topoisomerase II	A,B
	ec: 5.99.1.3 fragment: N-terminal ATPase Region

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Saccharomyces cerevisiae (taxid:4932)	Baker's yeast	Escherichia coli (taxid:562)
	gene: TOP2 expression_system_strain: BL21-CODONPLUS expression_system_vector_type: plasmid expression_system_plasmid: pet28b

Authors :

Classen, S., Olland, S., Berger, J.M.

Keywords :

GHKL ATPASE DOMAIN, ICRF, ICRF-187, DEXRAZOXANE, ISOMERASE

Exp. method :

X-RAY DIFFRACTION ( 1.90 Å )

Citation :

Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187

Classen, S.,Olland, S.,Berger, J.M.
(2003) Proc.Natl.Acad.Sci.USA 100 : 10629 - 10634

Chain :

A, B

UniProt :

P06786 (TOP2_YEAST)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP-dependent breakage, passage and rejoining of double- stranded DNA.	5.6.2.2	PROSITE-ProRule:PRU00995, PubMed:18097402, PubMed:23022727, PubMed:9685374
	-
Cofactor:	Evidence:	Note:
Ca(2+)	ECO:0000255 \| PROSITE-ProRule:PRU00995 ECO:0000269 \| PubMed:18097402 ECO:0000269 \| PubMed:20485342 ECO:0000255 \| PROSITE-ProRule:PRU00995 ECO:0000269 \| PubMed:18097402 ECO:0000269 \| PubMed:20485342 ECO:0000255 \| PROSITE-ProRule:PRU00995 ECO:0000269 \| PubMed:18097402 ECO:0000269 \| PubMed:20485342	Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).

PDB ID: 1QZR