Brand  (β version)

PDB ID: 1QZF

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Ligands
Code Name Style Show Link
UMP 2'-deoxyuridine 5'-monophosphate PoSSuM
CB3 10-propargyl-5,8-dideazafolic acid PoSSuM
FOL Folic acid PoSSuM
NDP Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate PoSSuM
Non-standard Residues
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Structure summary

Code : 1QZF   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE, TRANSFERASE
Title : Crystal structure of DHFR-TS from Cryptosporidium hominis
Release Data : 2003-11-11
Compound :
mol_id molecule chains
1 bifunctional dihydrofolate reductase-thymidylate synthase A,B,C,D,E
ec: 1.5.1.3, 2.1.1.45
Source :
mol_id organism_scientific expression_system
1 Cryptosporidium hominis  (taxid:237895) Escherichia coli  (taxid:562)
expression_system_strain: PA414
Authors : O'Neil, R.H., Lilien, R.H., Donald, B.R., Stroud, R.M., Anderson, A.C.
Keywords : bifunctional enzyme, OXIDOREDUCTASE, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.80 Å )
Citation :

Phylogenetic classification of protozoa based on the structure of the linker domain in the bifunctional enzyme, dihydrofolate reductase-thymidylate synthase

O'Neil, R.H.,Lilien, R.H.,Donald, B.R.  et al.
(2003)  J.Biol.Chem.  278 : 52980 - 52987

PubMed: 14555647
DOI: 10.1074/jbc.M310328200

Reaction

Chain : A, B, C, D, E
UniProt : Q27552 (Q27552_CRYPV)
Reaction: EC: Evidence:
Physiological Direction:
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8- dihydrofolate + dTMP 2.1.1.45 ARBA:ARBA00001707
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(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH 1.5.1.3 ARBA:ARBA00001315
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