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Ligands
Code Name Style Show Link
CDY 2-chlorodideoxyadenosine
M2M 1-methoxy-2-(2-methoxyethoxy)ethane
Non-standard Residues
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Glycosylation
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Code : 1QYE   PDBj   RCSB PDB   PDBe
Header : CHAPERONE
Title : Crystal Structure of the N-domain of the ER Hsp90 chaperone GRP94 in complex with 2-chlorodideoxyadenosine
Release Data : 2003-11-11
Compound :
mol_id molecule chains synonym
1 Endoplasmin A 94 kDa glucose-regulated protein, GRP94
fragment: Residues 69-337
Source :
mol_id organism_scientific organism_common expression_system
1 Canis lupus familiaris  (taxid:9615) Dog Escherichia coli BL21(DE3)  (taxid:469008)
strain: familiaris
gene: TRA1
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pGEXNB
Authors : Soldano, K.L., Jivan, A., Nicchitta, C.V., Gewirth, D.T.
Keywords : GRP94, gp96, hsp90, 2ClddA, 2-chlorodideoxyadenosine, CHAPERONE
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

Structure of the N-terminal Domain of GRP94. Basis for Ligand Specificity and Regulation

Soldano, K.L.,Jivan, A.,Nicchitta, C.V.  et al.
(2003)  J.Biol.Chem.  278 : 48330 - 48338

PubMed: 12970348
DOI: 10.1074/jbc.M308661200

Chain : A
UniProt : P41148 (ENPL_CANLF)
Reaction : -