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Ligands
Code Name Style Show Link
FR8 1-((1r)-1-(hydroxymethyl)-3-{6-[(5-phenylpentanoyl)amino]-1h-indol-1-yl}propyl)-1h-imidazole-4-carboxamide
ZN Zinc ion
Non-standard Residues
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Glycosylation
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Code : 1QXL   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of Adenosine deaminase complexed with FR235380
Release Data : 2004-09-21
Compound :
mol_id molecule chains synonym
1 Adenosine deaminase A Adenosine aminohydrolase
ec: 3.5.4.4
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Cattle
Authors : Kinoshita, T.
Keywords : beta barrel, zinc ion, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.25 Å )
Citation :

Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors

Terasaka, T.,Kinoshita, T.,Kuno, M.  et al.
(2004)  J.Med.Chem.  47 : 3730 - 3743

PubMed: 15239652
DOI: 10.1021/jm0306374

Chain : A
UniProt : P56658 (ADA_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
adenosine + H(+) + H2O = inosine + NH4(+) 3.5.4.4 UniProtKB:P00813
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2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+) 3.5.4.4 UniProtKB:P00813
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