Brand  (β version)

PDB ID: 1QXE

Hetero Atom Contents

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Code Name Style Show Link
SO4 Sulfate ion PoSSuM
OXY Oxygen molecule PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
FUX 5-hydroxymethyl-furfural PoSSuM

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Structure summary

Code : 1QXE   PDBj   RCSB PDB   PDBe
Header : OXYGEN STORAGE/TRANSPORT
Title : Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds
Release Data : 2003-09-16
Compound :
mol_id molecule chains
1 Hemoglobin alpha chain A,C
fragment: alpha chain
mol_id molecule chains
2 Hemoglobin beta chain B,D
fragment: beta chain
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
organ: blood
cell: erythrocytes
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
organ: blood
cell: erythrocytes
Authors : Safo, M.K., Abdulmalik, O., Danso-Danquah, R., Nokuri, S., Joshi, G.S., Musayev, F.N., Asakura, T., Abraham, D.J.
Keywords : allosteric; antisickling; relaxed state; hemoglobin; sickle cell; 5-hydroxymethyl-2-furfural, OXYGEN STORAGE-TRANSPORT COMPLEX
Exp. method : X-RAY DIFFRACTION ( 1.85 Å )
Citation :

Structural basis for the potent antisickling effect of a novel class of five-membered heterocyclic aldehydic compounds

Safo, M.K.,Abdulmalik, O.,Danso-Danquah, R.  et al.
(2004)  J.Med.Chem.  47 : 4665 - 4676

PubMed: 15341482
DOI: 10.1021/jm0498001

Reaction

Chain : A, C
UniProt : P69905 (HBA_HUMAN)
Reaction : -
Chain : B, D
UniProt : P68871 (HBB_HUMAN)
Reaction : -