Brand  (β version)

PDB ID: 1QVN

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
FRI 2-guanidino-4-methyl-pentanoic acid [2-(4-{5-[4-(4-acetylamino-benzyloxy)-2,3-dichloro-phenyl]-2-methyl-2h-pyrazol-3-yl}-piperidin-1-yl)-2-oxo-ethyl]-amide PoSSuM
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Structure summary

Code : 1QVN   PDBj   RCSB PDB   PDBe
Header : CYTOKINE
Title : Structure of SP4160 Bound to IL-2 V69A
Release Data : 2005-04-05
Compound :
mol_id molecule chains synonym
1 Interleukin-2 A,B,C,D IL-2, T-cell growth factor, TCGF, Aldesleukin
mutation: V69A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: IL2
Authors : Thanos, C.D., Delano, W.L., Wells, J.A.
Keywords : IL-2 Small Molecule hot spot, CYTOKINE
Exp. method : X-RAY DIFFRACTION ( 2.70 Å )
Citation :

Hot-spot mimicry of a cytokine receptor by a small molecule.

Thanos, C.D.,DeLano, W.L.,Wells, J.A.
(2006)  Proc.Natl.Acad.Sci.USA  103 : 15422 - 15427

PubMed: 17032757
DOI: 10.1073/pnas.0607058103

Reaction

Chain : A, B, C, D
UniProt : P60568 (IL2_HUMAN)
Reaction : -