Brand  (β version)

PDB ID: 1QSX

Hetero Atom Contents

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
HT 2'-(4-hydroxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bi-benzimidazole PoSSuM
NA Sodium ion PoSSuM

Structure summary

Code : 1QSX
Header : DNA
Title : SOLUTION NMR STRUCTURE OF THE 2:1 HOECHST 33258-D(CTTTTGCAAAAG)2 COMPLEX
Release Data : 2000-02-07
Compound :
mol_id molecule chains
1 5'-D(CP*TP*TP*TP*TP*GP*CP*AP*AP*AP*AP*G)-3' A,B
other_details: COMPLEXED WITH HOECHST 33258
Source :
mol_id organism_scientific
1
synthetic: yes
other_details: SOLID PHASE SYNTHESIS
Authors : Gavathiotis, E., Sharman, G.J., Searle, M.S.
Keywords : DRUG-DNA COMPLEX, HOECHST 33258, DEOXYRIBONUCLEIC ACID, MINOR GROOVE RECOGNITION, DOUBLE HELIX, NMR SPECTROSCOPY, DNA
Exp. method : SOLUTION NMR
Citation :

Sequence-dependent variation in DNA minor groove width dictates orientational preference of Hoechst 33258 in A-tract recognition: solution NMR structure of the 2:1 complex with d(CTTTTGCAAAAG)(2).

Gavathiotis, E.,Sharman, G.J.,Searle, M.S.
(2000)  Nucleic Acids Res.  28 : 728 - 735

PubMed: 10637324
DOI: 10.1093/nar/28.3.728

Sequence-Specific Interaction of Hoechst 33258 with the Minor Groove of an Adenine-Tract DNA Duplex Studied in Solution by 1H NMR Spectroscopy

Searle, M.S.,Embrey, K.J.
(1990)  Nucleic Acids Res.  18 : 3753 - 3762