Brand  (β version)

PDB ID: 1QPG

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Ligands
Code Name Style Show Link
3PG 3-phosphoglyceric acid PoSSuM
MAP Magnesium-5'-adenyly-imido-triphosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1QPG   PDBj   RCSB PDB   PDBe
Header : PHOSPHOTRANSFERASE (CARBOXYL ACCEPTOR)
Title : 3-PHOSPHOGLYCERATE KINASE, MUTATION R65Q
Release Data : 1996-06-10
Compound :
mol_id molecule chains synonym
1 3-PHOSPHOGLYCERATE KINASE A PGK
ec: 2.7.2.3
mutation: R65Q
Source :
mol_id organism_scientific organism_common expression_system
1 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast Saccharomyces cerevisiae  (taxid:4932)
expression_system_common: Baker's yeast
expression_system_strain: PGK-XSB44-35D
expression_system_plasmid: YEP9T-PGK
Authors : Mcphillips, T.M., Hsu, B.T., Sherman, M.A., Mas, M.T., Rees, D.C.
Keywords : PHOSPHOTRANSFERASE (CARBOXYL ACCEPTOR), KINASE, ACETYLATION, GLYCOLYSIS
Exp. method : X-RAY DIFFRACTION ( 2.4 Å )
Citation :

Structure of the R65Q mutant of yeast 3-phosphoglycerate kinase complexed with Mg-AMP-PNP and 3-phospho-D-glycerate.

McPhillips, T.M.,Hsu, B.T.,Sherman, M.A.  et al.
(1996)  Biochemistry  35 : 4118 - 4127

PubMed: 8672447
DOI: 10.1021/bi952500o

Characterization of the Structure and Properties of the His 62-->Ala and Arg 38-->Ala Mutants of Yeast Phosphoglycerate Kinase: An Investigation of the Catalytic and Activatory Sites by Site-Directed Mutagenesis and NMR

Sherman, M.A.,Fairbrother, W.J.,Mas, M.T.
(1992)  Protein Sci.  1 : 752

Site-Directed Mutations of Arginine 65 at the Periphery of the Active Site Cleft of Yeast 3-Phosphoglycerate Kinase Enhance the Catalytic Activity and Eliminate Anion-Dependent Activation

Sherman, M.A.,Dean, S.A.,Mathiowetz, A.M.  et al.
(1991)  Protein Eng.  4 : 935

Probing the Role of Arginines and Histidines in the Catalytic Function and Activation of Yeast 3-Phosphoglycerate Kinase by Site-Directed Mutagenesis

Sherman, M.A.,Szpikowska, B.K.,Dean, S.A.  et al.
(1990)  J.Biol.Chem.  265 : 10659

Reaction

Chain : A
UniProt : P00560 (PGK_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP 2.7.2.3 -
-