Het-PDB Navi2 (PDB: 1QFK)

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Ligands
Code	Name		Style	Show	Link
0Z6	D-phenylalanyl-N-[(2s,3s)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-phenylalaninamide				PoSSuM
CA	Calcium ion				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize
FUC	Alpha-L-fucopyranose
FUL	Beta-L-fucopyranose
GLC	Alpha-D-glucopyranose
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose

Modification
Code	Name	Show

Download interaction data: 1QFK

Code :

1QFK PDBj RCSB PDB PDBe

Header :

hydrolase/hydrolase inhibitor

Title :

STRUCTURE OF HUMAN FACTOR VIIA AND ITS IMPLICATIONS FOR THE TRIGGERING OF BLOOD COAGULATION

Release Data :

1999-08-01

Compound :

mol_id	molecule	chains	synonym
1	COAGULATION FACTOR VIIA LIGHT CHAIN	L	FVIIA
	ec: 3.4.21.21 fragment: UNP residues 109-212

mol_id	molecule	chains	synonym
2	COAGULATION FACTOR VIIA HEAVY CHAIN	H	FVIIA
	ec: 3.4.21.21 fragment: UNP residues 213-466

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Mesocricetus auratus (taxid:10036)
	tissue: BLOOD expression_system_common: Golden hamster expression_system_cell_line: BHK570 expression_system_organelle: NUCLEUS expression_system_cellular_location: SECRETED expression_system_vector_type: PLASMID expression_system_plasmid: ZEM219B expression_system_gene: FACTOR VII

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Mesocricetus auratus (taxid:10036)
	tissue: BLOOD expression_system_common: Golden hamster expression_system_cell_line: BHK570 expression_system_organelle: NUCLEUS expression_system_cellular_location: SECRETED expression_system_vector_type: PLASMID expression_system_plasmid: ZEM219B expression_system_gene: FACTOR VII

Authors :

Pike, A.C.W., Brzozowski, A.M., Roberts, S.M., Olsen, O.H., Persson, E.

Keywords :

BLOOD COAGULATION, SERINE PROTEASE, hydrolase-hydrolase inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 2.800 Å )

Citation :

Structure of human factor VIIa and its implications for the triggering of blood coagulation.

Pike, A.C.,Brzozowski, A.M.,Roberts, S.M. et al.
(1999) Proc.Natl.Acad.Sci.USA 96 : 8925 - 8930

Chain :

UniProt :

P08709 (FA7_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Selective cleavage of Arg-\|-Ile bond in factor X to form factor Xa.	3.4.21.21	-
	-	-

PDB ID: 1QFK