Brand  (β version)

PDB ID: 1QDQ

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Ligands
Code Name Style Show Link
074 [propylamino-3-hydroxy-butan-1,4-dionyl]-isoleucyl-proline PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1QDQ   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : X-RAY CRYSTAL STRUCTURE OF BOVINE CATHEPSIN B-CA074 COMPLEX
Release Data : 2000-07-10
Compound :
mol_id molecule chains
1 CATHEPSIN B A
ec: 3.4.22.1
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Cattle
Authors : Yamamoto, A.
Keywords : CATHEPSIN B, PAPAIN, CATHEPSIN B-SPECIFIC INHIBITOR COMPLEX, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.18 Å )
Citation :

Substrate specificity of bovine cathepsin B and its inhibition by CA074, based on crystal structure refinement of the complex.

Yamamoto, A.,Tomoo, K.,Hara, T.  et al.
(2000)  J.Biochem.(Tokyo)  127 : 635 - 643

PubMed: 10739956

Reaction

Chain : A
UniProt : P07688 (CATB_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C- terminal dipeptides. 3.4.22.1 PubMed:1856234
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