Brand  (β version)

PDB ID: 1QD3

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Ligands
Code Name Style Show Link
CYY 2-deoxystreptamine PoSSuM
BDG 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranose PoSSuM
IDG 2,6-diamino-2,6-dideoxy-beta-L-idopyranose PoSSuM
RIB Alpha-D-ribofuranose PoSSuM
: Polysaccharide
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Structure summary

Code : 1QD3   PDBj   RCSB PDB   PDBe
Header : RNA
Title : HIV-1 TAR RNA/NEOMYCIN B COMPLEX
Release Data : 2000-07-12
Compound :
mol_id molecule chains
1 HIV-1 TAR RNA A
fragment: RESIDUES 17-45
other_details: NEOMYCIN B (RESIDUES BDG-CYY-RYB-IDG) COMPLEXED IN THE RNA MINOR GROOVE
Source :
mol_id organism_scientific
1 Human immunodeficiency virus 1  (taxid:11676)
cell_line: Z2/CDC-Z34 ISOLATE
Authors : Faber, C., Sticht, H., Roesch, P.
Keywords : HIV-1, AMINOGLYCOSIDE-RNA-COMPLEX, MINOR GROOVE BINDING, RNA
Exp. method : SOLUTION NMR
Citation :

Structural rearrangements of HIV-1 Tat-responsive RNA upon binding of neomycin B.

Faber, C.,Sticht, H.,Schweimer, K.  et al.
(2000)  J.Biol.Chem.  275 : 20660 - 20666

PubMed: 10747964
DOI: 10.1074/jbc.M000920200

Binding of Neomycin to the Tar Element of HIV-1 RNA Induces Dissociation of Tat Protein by an Allosteric Mechanism

Wang, S.,Huber, P.W.,Mei, C.  et al.
(1998)  Biochemistry  37 : 5549

DOI: 10.1021/bi972808a