Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
FON N-{[4-({[(6r)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}-L-glutamic acid
GOL Glycerol
Code : 1QD1
Header : TRANSFERASE
Title : THE CRYSTAL STRUCTURE OF THE FORMIMINOTRANSFERASE DOMAIN OF FORMIMINOTRANSFERASE-CYCLODEAMINASE.
Release Data : 2000-01-12
Compound :
mol_id molecule chains
1 FORMIMINOTRANSFERASE-CYCLODEAMINASE A,B
ec: 2.1.2.5
fragment: FORMIMINOTRANSFERASE DOMAIN
Source :
mol_id organism_scientific organism_common expression_system
1 Sus scrofa  (taxid:9823) Pig Escherichia coli  (taxid:562)
organ: liver
expression_system_plasmid: pBke-Cm1
Authors : Kohls, D., Sulea, T., Purisima, E., MacKenzie, R.E., Vrielink, A.
Keywords : FUNCTIONAL DIMER, ALPHA-BETA-BETA-ALPHA SANDWICH, ELECTROSTATICALLY CHARGED SUBSTRATE TUNNEL, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.7 Å )
Citation :

The crystal structure of the formiminotransferase domain of formiminotransferase-cyclodeaminase: implications for substrate channeling in a bifunctional enzyme.

Kohls, D.,Sulea, T.,Purisima, E.O.  et al.
(2000)  Structure Fold.Des.  8 : 35 - 46

PubMed: 10673422
DOI: 10.1016/S0969-2126(00)00078-2

Chain : A, B
UniProt : P53603 (FTCD_PIG)
Reaction : 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate.
5-formyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formyl-L-glutamate.
5-formimidoyltetrahydrofolate = 5,10- methenyltetrahydrofolate + NH(3).