Brand  (β version)

PDB ID: 1QCA

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Ligands
Code Name Style Show Link
CO Cobalt (II) ion PoSSuM
FUA Fusidic acid PoSSuM
Non-standard Residues
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Structure summary

Code : 1QCA   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE (ACYLTRANSFERASE)
Title : QUADRUPLE MUTANT Q92C, N146F, Y168F, I172V TYPE III CAT COMPLEXED WITH FUSIDIC ACID. CRYSTALS GROWN AT PH 6.3. X-RAY DATA COLLECTED AT ROOM TEMPERATURE
Release Data : 1995-10-15
Compound :
mol_id molecule chains synonym
1 TYPE III CHLORAMPHENICOL ACETYLTRANSFERASE A CAT III
ec: 2.3.1.28
mutation: Q92C, N146F, Y168F, I172V
Source :
mol_id organism_scientific expression_system
1 Shigella flexneri  (taxid:623) Escherichia coli  (taxid:562)
expression_system_strain: JM101
expression_system_plasmid: PUC18
other_details: TRANSMISSIBLE PLASMID R387 ISOLATED FROM SHIGELLA FLEXNERI
Authors : Leslie, A.G.W.
Keywords : CHLORAMPHENICOL, FUSIDATE, STEROID, TRANSFERASE (ACYLTRANSFERASE)
Exp. method : X-RAY DIFFRACTION ( 2.2 Å )
Citation :

Steroid recognition by chloramphenicol acetyltransferase: engineering and structural analysis of a high affinity fusidic acid binding site.

Murray, I.A.,Cann, P.A.,Day, P.J.  et al.
(1995)  J.Mol.Biol.  254 : 993 - 1005

PubMed: 7500366
DOI: 10.1006/jmbi.1995.0671

Chloramphenicol Acetyltransferase

Shaw, W.V.,Leslie, A.G.W.
(1991)  Annu.Rev.Biophys.Biophys.Chem.  20 : 363

Refined Crystal Structure of Type III Chloramphenicol Acetyltransferase at 1.75-Angstroms Resolution

Leslie, A.G.W.
(1990)  J.Mol.Biol.  213 : 167

Structure of Chloramphenicol Acetyltransferase at 1.75-Angstroms Resolution

Leslie, A.G.W.,Moody, P.C.E.,Shaw, W.V.
(1988)  Proc.Natl.Acad.Sci.USA  85 : 4133

Reaction

Chain : A
UniProt : P00484 (CAT3_ECOLX)
Reaction: EC: Evidence:
Physiological Direction:
acetyl-CoA + chloramphenicol = chloramphenicol 3-acetate + CoA 2.3.1.28 PROSITE-ProRule:PRU10021
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