Brand  (β version)

PDB ID: 1Q41

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Ligands
Code Name Style Show Link
IXM (z)-1h,1'H-[2,3']biindolylidene-3,2'-dione-3-oxime PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1Q41   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : GSK-3 Beta complexed with Indirubin-3'-monoxime
Release Data : 2003-10-21
Compound :
mol_id molecule chains synonym
1 GLYCOGEN SYNTHASE KINASE-3 BETA A,B GSK-3 BETA
ec: 2.7.1.37
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: GSK3B
expression_system_common: Fall armyworm
expression_system_cell_line: H5
expression_system_vector: BACULOVIRUS
expression_system_plasmid: PVL-GST-GSK3BETA
Authors : Bertrand, J.A., Thieffine, S., Vulpetti, A., Cristiani, C., Valsasina, B., Knapp, S., Kalisz, H.M., Flocco, M.
Keywords : KINASE, INSULIN PATHWAY, Indirubin-3'-monoxime, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

Structural Characterization of the Gsk-3Beta Active Site Using Selective and Non-selective ATP-Mimetic Inhibitors

Bertrand, J.A.,Thieffine, S.,Vulpetti, A.  et al.
(2003)  J.Mol.Biol.  333 : 393 - 407

PubMed: 14529625
DOI: 10.1016/j.jmb.2003.08.031

Reaction

Chain : A, B
UniProt : P49841 (GSK3B_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl- [tau protein] 2.7.11.26 PubMed:14690523
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ATP + L-threonyl-[tau protein] = ADP + H(+) + O-phospho-L- threonyl-[tau protein] 2.7.11.26 PubMed:14690523
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ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:17050006, PubMed:22539723, PubMed:28992046
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:17050006
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