Brand  (β version)

PDB ID: 1Q2S

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
Non-standard Residues
Code Name Show
PQ1 Phosphoric acid mono-[5-(2-amino-5-aminomethyl-4-oxo-3,5-dihydro-4h-pyrido[2,3-D]pyrimidin-8-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester
Glycosylation
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Modification
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Structure summary

Code : 1Q2S   PDBj   RCSB PDB   PDBe
Header : Transferase/RNA
Title : Chemical trapping and crystal structure of a catalytic tRNA guanine transglycosylase covalent intermediate
Release Data : 2003-09-09
Compound :
mol_id molecule chains
1 5'-R(*AP*GP*CP*AP*CP*GP*GP*CP*UP*(PQ1)P*UP*AP*AP*AP*CP*CP*GP*UP*GP*C)-3' E
mol_id molecule chains
2 RNA (5'-R(*AP*GP*CP*AP*CP*GP*GP*CP*UP*(N)P*UP*AP*AP*AP*CP*CP*GP*UP*GP*C)-3') F
mol_id molecule chains synonym
3 Queuine tRNA-ribosyltransferase A,B,C,D tRNA-guanine transglycosylase, Guanine insertion enzyme
ec: 2.4.2.29
Source :
mol_id organism_scientific
1 Synthetic construct  (taxid:32630)
synthetic: yes
mol_id organism_scientific
2 Synthetic construct  (taxid:32630)
synthetic: yes
mol_id organism_scientific expression_system
3 Zymomonas mobilis  (taxid:542) Escherichia coli  (taxid:562)
strain: ZM4-CP4
atcc: 31821
gene: TGT
Authors : Xie, W., Liu, X., Huang, R.H.
Keywords : TIM barrel, Protein-RNA complex, Covalent intermediat, Transferase-RNA COMPLEX
Exp. method : X-RAY DIFFRACTION ( 3.2 Å )
Citation :

Chemical trapping and crystal structure of a catalytic tRNA guanine transglycosylase covalent intermediate

Xie, W.,Liu, X.,Huang, R.H.
(2003)  Nat.Struct.Biol.  10 : 781 - 788

PubMed: 12949492
DOI: 10.1038/nsb976

Reaction

Chain : A, B, C, D
UniProt : P28720 (TGT_ZYMMO)
Reaction: EC: Evidence:
Physiological Direction:
7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7- aminomethyl-7-carbaguanosine(34) in tRNA + guanine 2.4.2.29 HAMAP- Rule:MF_00168, PubMed:7665516
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