Het-PDB Navi2 (PDB: 1Q2O)

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Ligands
Code	Name	Link
ACT	Acetate ion	PoSSuM
CAC	Cacodylate ion	PoSSuM
DP1	L-N(omega)-nitroarginine-2,4-L-diaminobutyric amide	PoSSuM
GOL	Glycerol	PoSSuM
H4B	5,6,7,8-tetrahydrobiopterin	PoSSuM
HEM	Protoporphyrin ix containing Fe	PoSSuM
ZN	Zinc ion	PoSSuM

Non-standard Residues
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Download interaction data: 1Q2O

Code :

1Q2O PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

Bovine endothelial nitric oxide synthase N368D mutant heme domain dimer with L-N(omega)-nitroarginine-2,4-L-diaminobutyramide bound

Release Data :

2004-01-13

Compound :

mol_id	molecule	chains	synonym
1	Nitric-oxide synthase, endothelial	A,B	EC-NOS, NOS, type III, NOSIII, Endothelial NOS, eNOS, Constitutive NOS, cNOS
	ec: 1.14.13.39 fragment: heme domain of enos enzyme mutation: N368D

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Bos taurus (taxid:9913)	Cattle	Escherichia coli BL21(DE3) (taxid:469008)
	gene: NOS3 expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid expression_system_plasmid: pCWori

Authors :

Flinspach, M.L., Li, H., Jamal, J., Yang, W., Huang, H., Hah, J.M., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.

Keywords :

oxidoreductase, endothelial nitric oxide synthase, enos, nos III, heme protein

Exp. method :

X-RAY DIFFRACTION ( 1.74 Å )

Citation :

Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.

Flinspach, M.L.,Li, H.,Jamal, J. et al.
(2004) Nat.Struct.Mol.Biol. 11 : 54 - 59

Crystal Structure of Constitutive Endothelial Nitric Oxide Synthase: A Paradigm for Pterin Function Involving a Novel Metal Center

Raman, C.S.,Li, H.,Martasek, P. et al.
(1998) Cell(Cambridge,Mass.) 95 : 939 - 950

Chain :

A, B

UniProt :

P29473 (NOS3_BOVIN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
2 L-arginine + 3 NADPH + 4 O2 + H(+) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H2O	1.14.13.39	UniProtKB:P29474
	left-to-right	UniProtKB:P29474
Cofactor:	Evidence:	Note:
heme b	ECO:0000269 \| PubMed:11051558 ECO:0000269 \| PubMed:9875848	-
FAD	ECO:0000250 \| UniProtKB:P29476	Binds 1 FAD.
FMN	ECO:0000250 \| UniProtKB:P35228	Binds 1 FMN.
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin	ECO:0000269 \| PubMed:11051558 ECO:0000269 \| PubMed:11331003 ECO:0000269 \| PubMed:9875848	Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.

PDB ID: 1Q2O