Brand  (β version)

PDB ID: 1Q1Q

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Code Name Style Show Link
A3P Adenosine-3'-5'-diphosphate PoSSuM
NA Sodium ion PoSSuM
NHE 2-[N-cyclohexylamino]ethane sulfonic acid PoSSuM

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Structure summary

Code : 1Q1Q   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of human pregnenolone sulfotransferase (SULT2B1a) in the presence of PAP
Release Data : 2003-11-11
Compound :
mol_id molecule chains synonym
1 sulfotransferase family, cytosolic, 2B, member 1 isoform a A SULT2B1a
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: SULT2B1
expression_system_strain: BL21(DE3)RIL
expression_system_vector_type: PLASMID
expression_system_plasmid: PGEX-6P-3
Authors : Lee, K.A., Fuda, H., Lee, Y.C., Negishi, M., Strott, C.A., Pedersen, L.C.
Keywords : sulfotransferase, pregnenolone, SULT2B1, PAP, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.91 Å )
Citation :

Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms.

Lee, K.A.,Fuda, H.,Lee, Y.C.  et al.
(2003)  J.Biol.Chem.  278 : 44593 - 44599

PubMed: 12923182
DOI: 10.1074/jbc.M308312200

Reaction

Chain : A
UniProt : O00204 (ST2B1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
an alcohol + 3'-phosphoadenylyl sulfate = an alkyl sulfate + adenosine 3',5'-bisphosphate + H(+) 2.8.2.2 PubMed:12145317, PubMed:16855051, PubMed:19589875, PubMed:21855633, PubMed:9799594
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3beta-hydroxyandrost-5-en-17-one + 3'-phosphoadenylyl sulfate = dehydroepiandrosterone 3-sulfate + adenosine 3',5'-bisphosphate + H(+) - PubMed:12145317, PubMed:16855051, PubMed:21855633, PubMed:9799594
left-to-right ECO:0000305
(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)- hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+) - PubMed:19589875
left-to-right ECO:0000305
cholesterol + 3'-phosphoadenylyl sulfate = cholesterol sulfate + adenosine 3',5'-bisphosphate + H(+) - PubMed:12145317, PubMed:12923182
left-to-right ECO:0000305
pregnenolone + 3'-phosphoadenylyl sulfate = pregnenolone sulfate + adenosine 3',5'-bisphosphate + H(+) - PubMed:12145317, PubMed:12923182, PubMed:21855633
left-to-right ECO:0000305