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Ligands
Code Name Style Show Link
CIT Citric acid
FOM 3-[formyl(hydroxy)amino]propylphosphonic acid
NDP Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate
Non-standard Residues
Code Name Show
MSE Selenomethionine
Glycosylation
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Code : 1Q0H   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of selenomethionine-labelled DXR in complex with fosmidomycin
Release Data : 2004-07-20
Compound :
mol_id molecule chains synonym
1 1-deoxy-D-xylulose 5-phosphate reductoisomerase A DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, IspC
ec: 1.1.1.267
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli BL21(DE3)  (taxid:469008)
gene: DXR
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: pDS-6hisNdeI
Authors : Mac Sweeney, A., Lange, R., D'Arcy, A., Douangamath, A., Surivet, J.-P., Oefner, C.
Keywords : OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation.

Mac Sweeney, A.,Lange, R.,Fernandes, R.P.  et al.
(2005)  J.Mol.Biol.  345 : 115 - 127

PubMed: 15567415
DOI: 10.1016/j.jmb.2004.10.030

Chain : A
UniProt : P45568 (DXR_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D- xylulose 5-phosphate + H(+) + NADPH 1.1.1.267 PubMed:10631325, PubMed:10787409, PubMed:9707569
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