Brand  (β version)

PDB ID: 1PZP

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Ligands
Code Name Style Show Link
FTA 3-(4-phenylamino-phenylamino)-2-(1h-tetrazol-5-yl)-acrylonitrile PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1PZP   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : TEM-1 Beta-Lactamase in Complex with a Novel, Core-Disrupting, Allosteric Inhibitor
Release Data : 2004-03-09
Compound :
mol_id molecule chains synonym
1 Beta-lactamase TEM A TEM-1; TEM-2; TEM-3; TEM-4; TEM-5; TEM-6; TEM-8/CAZ-2; TEM-16/CAZ-7; TEM-24/CAZ-6; IRT-4; Penicillinase; TEM beta-lactamase; ampicillin resistance protein
ec: 3.5.2.6
mutation: R100N
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: bla
expression_system_vector_type: Plasmid
expression_system_plasmid: pAlter EX II-TEM-1
Authors : Horn, J.R., Shoichet, B.K.
Keywords : beta-lactamase, novel allosteric inhibitor, core-disruption, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.45 Å )
Citation :

Allosteric inhibition through core disruption.

Horn, J.R.,Shoichet, B.K.
(2004)  J.Mol.Biol.  336 : 1283 - 1291

PubMed: 15037085
DOI: 10.1016/j.jmb.2003.12.068

Reaction

Chain : A
UniProt : P62593 (BLAT_ECOLX)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 PROSITE-ProRule:PRU10101
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