PDB ID: 1PXJ
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Structure summary
Code : | 1PXJ PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE | ||||||||||||
Title : | HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-ylamine | ||||||||||||
Release Data : | 2003-12-09 | ||||||||||||
Compound : |
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Source : |
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Authors : | Wu, S.Y., McNae, I., Kontopidis, G., McClue, S.J., McInnes, C., Stewart, K.J., Wang, S., Zheleva, D.I., Marriage, H., Lane, D.P., Taylor, P., Fischer, P.M., Walkinshaw, M.D. | ||||||||||||
Keywords : | PROTEIN KINASE, CELL CYCLE, PHOSPHORYLATION, CELL DIVISION, MITOSIS, INHIBITION, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, 3D-STRUCTURE. | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.30 Å ) | ||||||||||||
Citation : |
Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop
Wu, S.Y.,McNae, I.,Kontopidis, G.
et al.
PubMed: 12679018 |
Reaction
Chain : | A | ||||||||||||
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UniProt : | P24941 (CDK2_HUMAN) | ||||||||||||
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