Brand  (β version)

PDB ID: 1PX4

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Ligands
Code Name Style Show Link
DMS Dimethyl sulfoxide PoSSuM
MG Magnesium ion PoSSuM
NA Sodium ion PoSSuM
IPT 1-methylethyl 1-thio-beta-D-galactopyranoside PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 1PX4   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : E. COLI (LACZ) BETA-GALACTOSIDASE (G794A) WITH IPTG BOUND
Release Data : 2004-06-15
Compound :
mol_id molecule chains synonym
1 beta-galactosidase A,B,C,D Lactase
ec: 3.2.1.23
mutation: G794A
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: lacZ
expression_system_strain: JM109
expression_system_vector_type: plasmid
expression_system_plasmid: pET15b (novagen)
Authors : Juers, D.H., Hakda, S., Matthews, B.W., Huber, R.E.
Keywords : loop conformation, Hydrolase
Exp. method : X-RAY DIFFRACTION ( 1.6 Å )
Citation :

Structural Basis for the Altered Activity of Gly794 Variants of Escherichia coli Beta-Galactosidase

Juers, D.H.,Hakda, S.,Matthews, B.W.  et al.
(2003)  Biochemistry  42 : 13505 - 13511

PubMed: 14621996
DOI: 10.1021/bi035506j

Reaction

Chain : A, B, C, D
UniProt : P00722 (BGAL_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. 3.2.1.23 -
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