Brand  (β version)

PDB ID: 1PWD

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Ligands
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0MU (2r)-5-(acetyloxymethyl)-2-[(1r)-1-[[(5r)-5-azanyl-6-oxidanyl-6-oxidanylidene-hexanoyl]amino]-2-oxidanylidene-ethyl]-5,6-dihydro-2h-1,3-thiazine-4-carboxylic acid PoSSuM
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Structure summary

Code : 1PWD   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/Antibiotic
Title : Covalent acyl enzyme complex of the Streptomyces R61 DD-peptidase with cephalosporin C
Release Data : 2004-07-13
Compound :
mol_id molecule chains synonym
1 D-alanyl-D-alanine carboxypeptidase precursor A DD-peptidase, DD-carboxypeptidase
ec: 3.4.16.4
fragment: DD-PEPTIDASE
Source :
mol_id organism_scientific
1 Streptomyces sp.  (taxid:31952)
strain: R61
Authors : Silvaggi, N.R., Josephine, H.R., Pratt, R.F., Kelly, J.A.
Keywords : BETA-LACTAM, ANTIBIOTICS, PENICILLIN BINDING PROTEIN, ENZYME, PEPTIDOGLYCAN, HYDROLASE, HYDROLASE-Antibiotic complex
Exp. method : X-RAY DIFFRACTION ( 1.20 Å )
Citation :

Crystal structures of complexes between the R61 DD-peptidase and peptidoglycan-mimetic beta-lactams: a non-covalent complex with a "perfect penicillin"

Silvaggi, N.R.,Josephine, H.R.,Kuzin, A.P.  et al.
(2005)  J.Mol.Biol.  345 : 521 - 533

PubMed: 15581896
DOI: 10.1016/j.jmb.2004.10.076

Structures of Two Kinetic Intermediates Reveal Species Specificity of Penicillin-Binding Proteins

Mcdonough, M.A.,Anderson, J.W.,Silvaggi, N.R.  et al.
(2002)  J.Mol.Biol.  322 : 111 - 122

DOI: 10.1016/S0022-2836(02)00742-8

A 1.2-A Snapshot of the Final Step of Bacterial Cell Wall Biosynthesis

Lee, W.,Mcdonough, M.A.,Kotra, L.  et al.
(2001)  Proc.Natl.Acad.Sci.USA  98 : 1427 - 1431

DOI: 10.1073/pnas.98.4.1427

The Refined Crystallographic Structure of a Dd-Peptidase Penicillin-Target Enzyme at 1.6 A Resolution

Kelly, J.A.,Kuzin, A.P.
(1995)  J.Mol.Biol.  254 : 223 - 236

DOI: 10.1006/jmbi.1995.0613

Reaction

Chain : A
UniProt : P15555 (DAC_STRSR)
Reaction: EC: Evidence:
Physiological Direction:
Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine. 3.4.16.4 -
-