Het-PDB Navi2 (PDB: 1PSA)

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Ligands
Code	Name		Style	Show	Link
0ZL	N-(ethoxycarbonyl)-L-leucyl-N-[(1r,2s,3s)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-leucinamide				PoSSuM

Non-standard Residues
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Glycosylation
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Modification
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Download interaction data: 1PSA

Code :

1PSA PDBj RCSB PDB PDBe

Header :

HYDROLASE/hydrolase inhibitor

Title :

STRUCTURE OF A PEPSIN(SLASH)RENIN INHIBITOR COMPLEX REVEALS A NOVEL CRYSTAL PACKING INDUCED BY MINOR CHEMICAL ALTERATIONS IN THE INHIBITOR

Release Data :

1994-01-31

Compound :

mol_id	molecule	chains
1	PEPSIN A	A,B
	ec: 3.4.23.1

Source :

mol_id	organism_scientific	organism_common
1	Sus scrofa (taxid:9823)	Pig

Authors :

Chen, L., Abad-Zapatero, C.

Keywords :

ACID PROTEINASE, HYDROLASE-hydrolase inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 2.9 Å )

Citation :

Structure of a pepsin/renin inhibitor complex reveals a novel crystal packing induced by minor chemical alterations in the inhibitor.

Chen, L.,Erickson, J.W.,Rydel, T.J. et al.
(1992) Acta Crystallogr.,Sect.B 48 : 476 - 488

PubMed: 1418819
DOI: 10.1107/S0108768192001939

Inhibitor Binding Induces Structural Changes in Porcine Pepsin

Abad-Zapatero, C.,Rydel, T.J.,Neidhart, D.J. et al.
(1991) Adv.Exp.Med.Biol. 306 : 9

Revised 2.3 Angstroms Structure of Porcine Pepsin: Evidence for a Flexible Subdomain

Abad-Zapatero, C.,Rydel, T.J.,Erickson, J.
(1990) Proteins 8 : 62

Chain :

A, B

UniProt :

P00791 (PEPA_PIG)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves 1-Phe-\|-Val-2, 4-Gln-\|-His- 5, 13-Glu-\|-Ala-14, 14-Ala-\|-Leu-15, 15-Leu-\|-Tyr-16, 16-Tyr-\|-Leu- 17, 23-Gly-\|-Phe-24, 24-Phe-\|-Phe-25 and 25-Phe-\|-Tyr-26 bonds in the B chain of insulin.	3.4.23.1	PROSITE- ProRule:PRU10094
	-	PROSITE- ProRule:PRU10094

PDB ID: 1PSA

Hetero Atom Contents

Structure summary

Reaction