Brand  (β version)

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Ligands
Code Name Link
J77 (methylpyridazine piperidine ethyloxyphenyl)ethylacetate
MYR Myristic acid
Code : 1PO2
Header : VIRUS
Title : POLIOVIRUS (TYPE 1, MAHONEY) IN COMPLEX WITH R77975, AN INHIBITOR OF VIRAL REPLICATION
Release Data : 1997-12-03
Compound :
mol_id molecule chains synonym
1 POLIOVIRUS TYPE 1 MAHONEY 0 P1/MAHONEY
mol_id molecule chains synonym
2 POLIOVIRUS TYPE 1 MAHONEY 1 P1/MAHONEY
mol_id molecule chains synonym
3 POLIOVIRUS TYPE 1 MAHONEY 2 P1/MAHONEY
mol_id molecule chains synonym
4 POLIOVIRUS TYPE 1 MAHONEY 3 P1/MAHONEY
mol_id molecule chains synonym
5 POLIOVIRUS TYPE 1 MAHONEY 4 P1/MAHONEY
Source :
mol_id organism_scientific
1 Human poliovirus 1  (taxid:12081)
strain: Mahoney
other_details: P1/MAHONEY PREPARED FROM A LOW-PASSAGE STOCK, PROVIDED BY MARIE CHOW, OF A PLAQUE ISOLATED FROM HELA CELLS TRANSFECTED WITH AN INFECTIOUS CDNA CLONE OF THE VIRAL GENOME. THE ANTIVIRAL COMPOUND R77975 WAS DEVELOPED BY JANSSEN PHARMACEUTICA.
mol_id organism_scientific
2 Human poliovirus 1  (taxid:12081)
strain: Mahoney
cell_line: HELA
other_details: P1/MAHONEY PREPARED FROM A LOW-PASSAGE STOCK, PROVIDED BY MARIE CHOW, OF A PLAQUE ISOLATED FROM HELA CELLS TRANSFECTED WITH AN INFECTIOUS CDNA CLONE OF THE VIRAL GENOME. THE ANTIVIRAL COMPOUND R77975 WAS DEVELOPED BY JANSSEN PHARMACEUTICA.
mol_id organism_scientific
3 Human poliovirus 1  (taxid:12081)
strain: Mahoney
cell_line: HELA
other_details: P1/MAHONEY PREPARED FROM A LOW-PASSAGE STOCK, PROVIDED BY MARIE CHOW, OF A PLAQUE ISOLATED FROM HELA CELLS TRANSFECTED WITH AN INFECTIOUS CDNA CLONE OF THE VIRAL GENOME. THE ANTIVIRAL COMPOUND R77975 WAS DEVELOPED BY JANSSEN PHARMACEUTICA.
mol_id organism_scientific
4 Human poliovirus 1  (taxid:12081)
strain: Mahoney
cell_line: HELA
other_details: P1/MAHONEY PREPARED FROM A LOW-PASSAGE STOCK, PROVIDED BY MARIE CHOW, OF A PLAQUE ISOLATED FROM HELA CELLS TRANSFECTED WITH AN INFECTIOUS CDNA CLONE OF THE VIRAL GENOME. THE ANTIVIRAL COMPOUND R77975 WAS DEVELOPED BY JANSSEN PHARMACEUTICA.
mol_id organism_scientific
5 Human poliovirus 1  (taxid:12081)
strain: Mahoney
cell_line: HELA
other_details: P1/MAHONEY PREPARED FROM A LOW-PASSAGE STOCK, PROVIDED BY MARIE CHOW, OF A PLAQUE ISOLATED FROM HELA CELLS TRANSFECTED WITH AN INFECTIOUS CDNA CLONE OF THE VIRAL GENOME. THE ANTIVIRAL COMPOUND R77975 WAS DEVELOPED BY JANSSEN PHARMACEUTICA.
Authors : Hiremath, C.N., Filman, D.J., Grant, R.A., Hogle, J.M.
Keywords : POLIOVIRUS, PICORNAVIRUS COAT PROTEIN, ANTI-VIRAL DRUGS, HYDROLASE, THIOL PROTEASE, Icosahedral virus, Virus
Exp. method : X-RAY DIFFRACTION ( 2.9 Å )
Citation :

Ligand-induced conformational changes in poliovirus-antiviral drug complexes.

Hiremath, C.N.,Filman, D.J.,Grant, R.A.  et al.
(1997)  Acta Crystallogr.,Sect.D  53 : 558 - 570

PubMed: 15299887
DOI: 10.1107/S0907444997000954

Binding of the Antiviral Drug Win51711 to the Sabin Strain of Type 3 Poliovirus: Structural Comparison with Drug Binding in Rhinovirus 14

Hiremath, C.N.,Grant, R.A.,Filman, D.J.  et al.
(1995)  Acta Crystallogr.,Sect.D  51 : 473

Structures of Poliovirus Complexes with Anti-Viral Drugs: Implications for Viral Stability and Drug Design

Grant, R.A.,Hiremath, C.N.,Filman, D.J.  et al.
(1994)  Curr.Biol.  4 : 784

Role of Conformational Transitions in Poliovirus Assembly and Cell Entry

Hogle, J.M.,Syed, R.,Fricks, C.E.  et al.
(1990)  New Aspects of Positive-Strand RNA Viruses  : 199

Structural Factors that Control Conformational Transitions and Serotype Specificity in Type 3 Poliovirus

Filman, D.J.,Syed, R.,Chow, M.  et al.
(1989)  Embo J.  8 : 1567

Myristylation of Picornavirus Capsid Protein Vp4 and its Structural Significance

Chow, M.,Newman, J.F.,Filman, D.  et al.
(1987)  Nature  327 : 482

Three-Dimensional Structure of Poliovirus at 2.9 A Resolution

Hogle, J.M.,Chow, M.,Filman, D.J.
(1985)  Science  229 : 1358

The Nucleotide Sequence of Poliovirus Type 3 Leon 12 A1B: Comparison with Poliovirus Type 1

Stanway, G.,Cann, A.J.,Hauptmann, R.  et al.
(1983)  Nucleic Acids Res.  11 : 5629

Chain : 3
UniProt : P03300 (POLG_POL1M)
Reaction : Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein.
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
NTP + H(2)O = NDP + phosphate.