Brand  (β version)

PDB ID: 1PJP

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
Non-standard Residues
Code Name Show
HPH (2s)-2-amino-3-phenylpropane-1,1-diol
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show
0QE Chloromethane
SIN Succinic acid

Structure summary

Code : 1PJP   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : THE 2.2 A CRYSTAL STRUCTURE OF HUMAN CHYMASE IN COMPLEX WITH SUCCINYL-ALA-ALA-PRO-PHE-CHLOROMETHYLKETONE
Release Data : 1999-03-02
Compound :
mol_id molecule chains synonym
1 CHYMASE A MAST CELL PROTEASE I
ec: 3.4.21.39
mutation: F127K, V208A, R235Q
mol_id molecule chains
2 SUCCINYL-ALA-ALA-PRO-PHE-CHLOROMETHYLKETONE INHIBITOR I
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
cell: MAST CELLS
expression_system_common: Fall armyworm
mol_id organism_scientific
2
synthetic: yes
Authors : Pereira, P.J.B., Wang, Z.M., Rubin, H., Huber, R., Bode, W., Schechter, N.M., Strobl, S.
Keywords : HUMAN CHYMASE, SERINE PROTEINASE, DIPEPTIDYL CARBOXYPEPTIDASE, ANGIOTENSIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.2 Å )
Citation :

The 2.2 A crystal structure of human chymase in complex with succinyl-Ala-Ala-Pro-Phe-chloromethylketone: structural explanation for its dipeptidyl carboxypeptidase specificity.

Pereira, P.J.,Wang, Z.M.,Rubin, H.  et al.
(1999)  J.Mol.Biol.  286 : 163 - 173

PubMed: 9931257
DOI: 10.1006/jmbi.1998.2462

Crystal Structure of Phenylmethanesulfonyl Fluoride-Treated Human Chymase at 1.9 A

McGrath, M.E.,Mirzadegan, T.,Schmidt, B.F.
(1997)  Biochemistry  36 : 14318 - 14324

Reaction

Chain : A
UniProt : P23946 (CMA1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Preferential cleavage: Phe-|-Xaa > Tyr-|-Xaa > Trp-|-Xaa > Leu-|-Xaa. 3.4.21.39 -
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