Brand  (β version)

PDB ID: 1PJL

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Ligands
Code Name Style Show Link
LU Lutetium (III) ion PoSSuM
NAD Nicotinamide-adenine-dinucleotide PoSSuM
Non-standard Residues
Code Name Show
MSE Selenomethionine
Glycosylation
Code Name Emphasize
Modification
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Structure summary

Code : 1PJL   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of human M-NAD-ME in ternary complex with NAD and Lu3+
Release Data : 2003-06-17
Compound :
mol_id molecule chains synonym
1 NAD-dependent malic enzyme, mitochondrial A,B,C,D,E,F,G,H NAD-ME, Malic enzyme 2
ec: 1.1.1.38
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: ME2
Authors : Yang, Z., Batra, R., Floyd, D.L., Hung, H.-C., Chang, G.-G., Tong, L.
Keywords : OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.9 Å )
Citation :

Potent and competitive inhibition of malic enzymes by lanthanide ions

Yang, Z.,Batra, R.,Floyd, D.L.  et al.
(2000)  Biochem.Biophys.Res.Commun.  274 : 440 - 444

PubMed: 10913357
DOI: 10.1006/bbrc.2000.3163

Reaction

Chain : A, B, C, D, E, F, G, H
UniProt : P23368 (MAOM_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
(S)-malate + NAD(+) = pyruvate + CO2 + NADH 1.1.1.38 PubMed:12121650, PubMed:1993674
-
oxaloacetate + H(+) = pyruvate + CO2 1.1.1.38 PubMed:12121650, PubMed:1993674
-
Cofactor: Evidence: Note:
Mn(2+) ECO:0000269 | PubMed:10700286
ECO:0000269 | PubMed:12121650
ECO:0000269 | PubMed:12962632
ECO:0000269 | PubMed:10700286
ECO:0000269 | PubMed:12121650
ECO:0000269 | PubMed:12962632
Divalent metal cations. Prefers magnesium or manganese.