Brand  (β version)

PDB ID: 1PD8

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Ligands
Code Name Style Show Link
CO4 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxy-N-methylanilino)methyl]pyrido[2,3-D]pyrimidine PoSSuM
NDP Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate PoSSuM
Non-standard Residues
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Structure summary

Code : 1PD8   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Analysis of Three Crystal Structure Determinations of a 5-Methyl-6-N-Methylanilino Pyridopyrimidine Antifolate Complex with Human Dihydrofolate Reductase
Release Data : 2003-12-09
Compound :
mol_id molecule chains
1 Dihydrofolate reductase A
ec: 1.5.1.3
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: DHFR
Authors : Cody, V., Luft, J.R., Pangborn, W., Gangjee, A.
Keywords : human dihydrofolate reductase inhibitor complex, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.1 Å )
Citation :

Analysis of three crystal structure determinations of a 5-methyl-6-N-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase.

Cody, V.,Luft, J.R.,Pangborn, W.  et al.
(2003)  Acta Crystallogr.,Sect.D  59 : 1603 - 1609

PubMed: 12925791
DOI: 10.1107/S0907444903014963

Reaction

Chain : A
UniProt : P00374 (DYR_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH 1.5.1.3 PROSITE- ProRule:PRU00660, PubMed:12096917, PubMed:15039552, PubMed:17569517, PubMed:19196009, PubMed:19478082, PubMed:21876184, PubMed:9719595
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