Het-PDB Navi2 (PDB: 1PCG)

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Ligands
Code	Name		Style	Show	Link
EST	Estradiol				PoSSuM

Non-standard Residues
Code	Name	Show
DCY	D-cysteine

Glycosylation
Code	Name	Emphasize

Modification
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Download interaction data: 1PCG

Code :

1PCG PDBj RCSB PDB PDBe

Header :

TRANSCRIPTION/INHIBITOR

Title :

Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions

Release Data :

2003-10-28

Compound :

mol_id	molecule	chains	synonym
1	estrogen receptor	A,B	ER, Estradiol receptor, ER-alpha
	fragment: ligand-binding domain mutation: C381S, C417S, C530S

mol_id	molecule	chains
2	peptide inhibitor	E,F
	other_details: The sequence of the peptide is LYS-DCY-ILE-LEU-CYS-ARG-LEU-LEU-GLN.

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	expression_system_strain: BL21(DE3)

mol_id	organism_scientific
2
	synthetic: yes

Authors :

Leduc, A.M., Trent, J.O., Wittliff, J.L., Bramlett, K.S., Briggs, S.L., Chirgadze, N.Y., Wang, Y., Burris, T.P., Spatola, A.F.

Keywords :

co-activator binding site, TRANSCRIPTION-INHIBITOR COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 2.70 Å )

Citation :

Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions

Leduc, A.M.,Trent, J.O.,Wittliff, J.L. et al.
(2003) Proc.Natl.Acad.Sci.USA 100 : 11273 - 11278

PDB ID: 1PCG