Het-PDB Navi2 (PDB: 1PBB)

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Ligands
Code	Name		Style	Show	Link
DOB	2,4-dihydroxybenzoic acid				PoSSuM
FAD	Flavin-adenine dinucleotide				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1PBB

Code :

1PBB PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

CRYSTAL STRUCTURES OF WILD-TYPE P-HYDROXYBENZOATE HYDROXYLASE COMPLEXED WITH 4-AMINOBENZOATE, 2,4-DIHYDROXYBENZOATE AND 2-HYDROXY-4-AMINOBENZOATE AND OF THE TRY222ALA MUTANT, COMPLEXED WITH 2-HYDROXY-4-AMINOBENZOATE. EVIDENCE FOR A PROTON CHANNEL AND A NEW BINDING MODE OF THE FLAVIN RING

Release Data :

1994-09-30

Compound :

mol_id	molecule	chains
1	P-HYDROXYBENZOATE HYDROXYLASE	A
	ec: 1.14.13.2

Source :

mol_id	organism_scientific
1	Pseudomonas fluorescens (taxid:294)

Authors :

Schreuder, H.A., Mattevi, A., Hol, W.G.J.

Keywords :

OXIDOREDUCTASE

Exp. method :

X-RAY DIFFRACTION ( 2.50 Å )

Citation :

Crystal structures of wild-type p-hydroxybenzoate hydroxylase complexed with 4-aminobenzoate,2,4-dihydroxybenzoate, and 2-hydroxy-4-aminobenzoate and of the Tyr222Ala mutant complexed with 2-hydroxy-4-aminobenzoate. Evidence for a proton channel and a new binding mode of the flavin ring

Schreuder, H.A.,Mattevi, A.,Obmolova, G. et al.
(1994) Biochemistry 33 : 10161 - 10170

PubMed: 7520279
DOI: 10.1021/bi00199a044

Crystal Structure of the Reduced Form of P-Hydroxybenzoate Hydroxylase Refined at 2.3 Angstroms Resolution

Schreuder, H.A.,Van Der Laan, J.M.,Swarte, M.B.A. et al.
(1992) Proteins 14 : 178

The Influence of Purification and Protein Heterogeneity on the Crystallization of P-Hydroxybenzoate Hydroxylase

Van Der Laan, J.M.,Swarte, M.B.A.,Groendijk, H. et al.
(1989) Eur.J.Biochem. 179 : 715

The Coenzyme Analogue Adenosine 5-Diphosphoribose Displaces Fad in the Active Site of P-Hydroxybenzoate Hydroxylase. An X-Ray Crystallographic Investigation

Van Der Laan, J.M.,Schreuder, H.A.,Swarte, M.B.A. et al.
(1989) Biochemistry 28 : 7199

Analysis of the Active Site of the Flavoprotein P-Hydroxybenzoate Hydroxylase and Some Ideas with Respect to its Reaction Mechanism

Schreuder, H.A.,Hol, W.G.J.,Drenth, J.
(1989) Biochemistry 29 : 3101

Crystal Structure of the P-Hydroxybenzoate Hydroxylase-Substrate Complex Refined at 1.9 Angstroms Resolution. Analysis of the Enzyme-Substrate and Enzyme-Product Complexes

Schreuder, H.A.,Prick, P.A.J.,Wierenga, R.K. et al.
(1989) J.Mol.Biol. 208 : 679

Molecular Modeling Reveals the Possible Importance of a Carbonyl Oxygen Binding Pocket for the Catalytic Mechanism of P-Hydroxybenzoate Hydroxylase

Schreuder, H.A.,Hol, W.G.J.,Drenth, J.
(1988) J.Biol.Chem. 263 : 3131

Crystal Structure of P-Hydroxybenzoate Hydroxylase Complexed with its Reaction Product 3,4-Dihydroxybenzoate

Schreuder, H.A.,Van Der Laan, J.M.,Hol, W.G.J. et al.
(1988) J.Mol.Biol. 199 : 637

Comparison of the Three-Dimensional Protein and Nucleotide Structure of the Fad-Binding Domain of P-Hydroxybenzoate Hydroxylase with the Fad-as Well as Nadph-Binding Domains of Glutathione Reductase

Wierenga, R.K.,Drenth, J.,Schulz, G.E.
(1983) J.Mol.Biol. 167 : 725

Crystal Structure of P-Hydroxybenzoate Hydroxylase

Wierenga, R.K.,De Jong, R.J.,Kalk, K.H. et al.
(1979) J.Mol.Biol. 131 : 55

Crystallization and Preliminary X-Ray Investigation of P-Hydroxybenzoate Hydroxylase from Pseudomonas Fluorescens

Drenth, J.,Hol, W.G.J.,Wierenga, R.K.
(1975) J.Biol.Chem. 250 : 5268

Chain :

UniProt :

P00438 (PHHY_PSEFL)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
4-hydroxybenzoate + H(+) + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP(+)	1.14.13.2	PubMed:10025942, PubMed:10493859, PubMed:1459126, PubMed:7628466, PubMed:7756982, PubMed:9578477, PubMed:9694855
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PDB ID: 1PBB

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