Brand  (β version)

color scheme of protein:

chain: Hide other chain(s)

Modified Residues
Code Name Link
0QE Chloromethane
ACE Acetyl group
Code : 1PAD
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Binding of chloromethyl ketone substrate analogues to crystalline papain
Release Data : 1977-04-12
Compound :
mol_id molecule chains
1 PAPAIN A
ec: 3.4.22.2
mol_id molecule chains synonym
2 ACETYL-ALA-ALA-PHE-ALA-CHLOROMETHYLKETONE INHIBITOR I ACAAPACK
Source :
mol_id organism_scientific organism_common
1 Carica papaya  (taxid:3649) Papaya
tissue: FRUIT LATEX
mol_id organism_scientific
2
synthetic: yes
Authors : Drenth, J., Kalk, K.H., Swen, H.M.
Keywords : SULFHYDRYL PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.8 Å )
Citation :

Binding of chloromethyl ketone substrate analogues to crystalline papain.

Drenth, J.,Kalk, K.H.,Swen, H.M.
(1976)  Biochemistry  15 : 3731 - 3738

PubMed: 952885
DOI: 10.1021/bi00662a014

The Structure of Papain

Drenth, J.,Jansonius, J.N.,Koekoek, R.  et al.
(1971)  Adv.Protein Chem.  25 : 79

The Structure of the Papain Molecule

Drenth, J.,Jansonius, J.N.,Koekoek, R.  et al.
(1970)  Philos.Trans.R.Soc.London,Ser.B  257 : 231

Structure of Papain

Drenth, J.,Jansonius, J.N.,Koekoek, R.  et al.
(1968)  Nature  218 : 929

?


(1976)  Atlas of Macromolecular Structure on Microfiche  : 250

?


(1972)  Atlas of Protein Sequence and Structure (Data Section)  5 : 121

Chain : A
UniProt : P00784 (PAPA1_CARPA)
Reaction : Hydrolysis of proteins with broad specificity for peptide bonds, but preference for an amino acid bearing a large hydrophobic side chain at the P2 position. Does not accept Val in P1'.