Brand  (β version)

PDB ID: 1P9U

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Ligands
Code Name Style Show Link
SO4 Sulfate ion PoSSuM
MRD (4r)-2-methylpentane-2,4-diol PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
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0QE Chloromethane

Structure summary

Code : 1P9U   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of anti-SARS Drugs
Release Data : 2003-05-20
Compound :
mol_id molecule chains
1 putative coronavirus nsp2 (3CL-PRO) A,B,C,D,E,F
fragment: TGEV main proteinase
mol_id molecule chains
2 PHQ-VNSTLQ-CHLOROMETHYLKETONE INHIBITOR G,H
Source :
mol_id organism_scientific expression_system
1 Transmissible gastroenteritis virus  (taxid:11149) Escherichia coli  (taxid:562)
gene: ORF1a
expression_system_strain: TB1
expression_system_vector_type: plasmid
expression_system_plasmid: pMal-Mpro
mol_id organism_scientific
2
synthetic: yes
other_details: substrate-analog
Authors : Anand, K., Ziebuhr, J., Wadhwani, P., Mesters, J.R., Hilgenfeld, R.
Keywords : SARS-COV, HCOV, TGEV, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.37 Å )
Citation :

Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of anti-SARS Drugs

Anand, K.,Ziebuhr, J.,Wadhwani, P.  et al.
(2003)  Science  300 : 1763 - 1767

PubMed: 12746549
DOI: 10.1126/science.1085658

Reaction

Chain : A, B, C, D, E, F
UniProt : Q9IW06 (R1A_CVPPU)
Reaction: EC: Evidence:
Physiological Direction:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal). 3.4.19.12 -
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