Brand  (β version)

PDB ID: 1P8D

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Ligands
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CO1 17-[3-(3,3-dimethyl-oxiranyl)-1-methyl-propyl]-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-3-ol PoSSuM
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Structure summary

Code : 1P8D   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN/PROTEIN BINDING
Title : X-Ray Crystal Structure of LXR Ligand Binding Domain with 24(S),25-epoxycholesterol
Release Data : 2003-07-08
Compound :
mol_id molecule chains synonym
1 Oxysterols receptor LXR-beta A,B Liver X receptor beta, Nuclear orphan receptor LXR-beta, Ubiquitously-expressed nuclear receptor, Nuclear receptor NER
fragment: Liver X Receptor beta ligand binding domain (residues 214-461)
mol_id molecule chains synonym
2 nuclear receptor coactivator 1 isoform 3 C,D Steroid Receptor Co-activator 1, SRC1
fragment: Steroid Receptor Co-activator 1 (residues 676-700)
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: NR1H2 OR LXRB OR UNR OR NER
expression_system_strain: BL21[DE3]
expression_system_vector_type: plasmid
expression_system_plasmid: pHTC
mol_id organism_scientific
2
synthetic: yes
other_details: Pepetide synthesis
Authors : Williams, S., Bledsoe, R.K., Collins, J.L., Boggs, S., Lambert, M.H., Miller, A.B., Moore, J., McKee, D.D., Moore, L., Nichols, J., Parks, D., Watson, M., Wisely, B., Willson, T.M.
Keywords : LXR, epoxycholesterol, nuclear receptor, steroid receptor, liver X receptor, transcription, MEMBRANE PROTEIN-PROTEIN BINDING COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.8 Å )
Citation :

X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch.

Williams, S.,Bledsoe, R.K.,Collins, J.L.  et al.
(2003)  J.Biol.Chem.  278 : 27138 - 27143

PubMed: 12736258
DOI: 10.1074/jbc.M302260200

Reaction

Chain : A, B
UniProt : P55055 (NR1H2_HUMAN)
Reaction : -