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Ligands
Code Name Style Show Link
CR4 2-{5-[amino(iminio)methyl]-1h-benzimidazol-2-yl}benzenolate
Non-standard Residues
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Glycosylation
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Code : 1P57   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Extracellular domain of human hepsin
Release Data : 2004-01-20
Compound :
mol_id molecule chains synonym
1 Serine protease hepsin A Transmembrane protease, serine 1
ec: 3.4.21.-
fragment: Residues 1-114 (Light chain)
mutation: N112A
mol_id molecule chains synonym
2 Serine protease hepsin B Transmembrane protease, serine 1
ec: 3.4.21.-
fragment: Residues 16-255 (Heavy chain)
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Pichia pastoris  (taxid:4922)
expression_system_strain: KM71
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Pichia pastoris  (taxid:4922)
expression_system_strain: KM71
Authors : Somoza, J.R., Ho, J.D., Luong, C., Sprengeler, P.A., Mortara, K., Shrader, W.D., Sperandio, D., Chan, H., McGrath, M.E., Katz, B.A.
Keywords : srcr, scavenger receptor cysteine-rich domain, serine protease, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.75 Å )
Citation :

The Structure of the Extracellular Region of Human Hepsin Reveals a Serine Protease Domain and a Novel Scavenger Receptor Cysteine-Rich (SRCR) Domain

Somoza, J.R.,Ho, J.D.,Luong, C.  et al.
(2003)  Structure  11 : 1123 - 1131

PubMed: 12962630
DOI: 10.1016/S0969-2126(03)00148-5

Chain : B
UniProt : P05981 (HEPS_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Cleavage after basic amino-acid residues, with Arg strongly preferred to Lys. 3.4.21.106 PubMed:15839837, PubMed:21875933, PubMed:26673890
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