Brand  (β version)

PDB ID: 1P0M

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Ligands
Code Name Style Show Link
CHT Choline ion PoSSuM
CL Chloride ion PoSSuM
GOL Glycerol PoSSuM
MES 2-(N-morpholino)-ethanesulfonic acid PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
FUC Alpha-L-fucopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Structure summary

Code : 1P0M   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of human butyryl cholinesterase in complex with a choline molecule
Release Data : 2003-08-05
Compound :
mol_id molecule chains synonym
1 Cholinesterase A Acylcholine acylhydrolase, Choline esterase II, Butyrylcholine esterase, Pseudocholinesterase
ec: 3.1.1.8
mutation: N17Q, N455Q, N481Q, N486Q
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Cricetulus griseus  (taxid:10029)
gene: BCHE OR CHE1
expression_system_common: Chinese hamster
expression_system_cell_line: ovary cells
Authors : Nicolet, Y., Lockridge, O., Masson, P., Fontecilla-Camps, J.C., Nachon, F.
Keywords : serine hydrolase, choline, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.38 Å )
Citation :

Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products.

Nicolet, Y.,Lockridge, O.,Masson, P.  et al.
(2003)  J.Biol.Chem.  278 : 41141 - 41147

PubMed: 12869558
DOI: 10.1074/jbc.M210241200

Engineering of a monomeric and low-glycosylated form of human butyrylcholinesterase: expression, purification, characterization and crystallization

Nachon, F.,Nicolet, Y.,Viguie, N.  et al.
(2002)  Eur.J.Biochem.  269 : 630 - 637

DOI: 10.1046/j.0014-2956.2001.02692.x

Reaction

Chain : A
UniProt : P06276 (CHLE_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
an acylcholine + H2O = a carboxylate + choline + H(+) 3.1.1.8 PubMed:19368529, PubMed:19452557
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