Brand  (β version)

PDB ID: 1OZ1

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Ligands
Code Name Style Show Link
FPH 3-(4-fluorophenyl)-2-pyridin-4-yl-1h-pyrrolo[3,2-B]pyridin-1-ol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1OZ1   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : P38 MITOGEN-ACTIVATED KINASE IN COMPLEX WITH 4-AZAINDOLE INHIBITOR
Release Data : 2003-09-23
Compound :
mol_id molecule chains synonym
1 Mitogen-activated protein kinase 14 A Mitogen-activated protein kinase p38alpha, MAP kinase p38alpha, Cytokine suppressive anti-inflammatory drug binding protein, CSAID binding protein, CSBP, MAX-interacting protein 2, MAP kinase MXI2, SAPK2A
ec: 2.7.1.37
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: MAPK14 OR CSBP1 OR CSBP2 OR CSBP OR MXI2
expression_system_strain: m15[prep4]
expression_system_vector_type: plasmid
expression_system_vector: pqe9
Authors : Lovejoy, B., Villasenor, A., Browner, M., Dunten, P.
Keywords : SER/THR PROTEIN KINASE, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

Design and synthesis of 4-azaindoles as inhibitors of p38 MAP kinase.

Trejo, A.,Arzeno, H.,Browner, M.  et al.
(2003)  J.Med.Chem.  46 : 4702 - 4713

PubMed: 14561090
DOI: 10.1021/jm0301787

Reaction

Chain : A
UniProt : Q16539 (MK14_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.24 PubMed:11010976, PubMed:35857590
left-to-right
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.24 PubMed:11010976, PubMed:35857590
left-to-right
Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:10838079
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