Brand  (β version)

PDB ID: 1OX4

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Ligands
Code Name Style Show Link
SO4 Sulfate ion PoSSuM
NI Nickel (II) ion PoSSuM
POP Pyrophosphate 2- PoSSuM
Non-standard Residues
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Glycosylation
Code Name Emphasize
Modification
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Structure summary

Code : 1OX4   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE, LYASE
Title : TOWARDS UNDERSTANDING THE MECHANISM OF THE COMPLEX CYCLIZATION REACTION CATALYZED BY IMIDAZOLE GLYCEROPHOSPHATE SYNTHASE
Release Data : 2003-06-17
Compound :
mol_id molecule chains synonym
1 Imidazole glycerol phosphate synthase hisHF A HISTIDINE BIOSYNTHESIS BIFUNCTIONAL AMIDOTRANSFERASE; IGP synthase; ImGP synthase; IGPS; glutamine amidotransferase:cyclase
ec: 2.4.2.-, 4.1.3.-
fragment: AMIDOTRANSFERASE AND CYCLASE DOMAINS
mol_id molecule chains synonym
2 Imidazole glycerol phosphate synthase hisHF B HISTIDINE BIOSYNTHESIS BIFUNCTIONAL AMIDOTRANSFERASE; IGP synthase; ImGP synthase; IGPS; glutamine amidotransferase:cyclase
ec: 2.4.2.-, 4.1.3.-
fragment: AMIDOTRANSFERASE AND CYCLASE DOMAINS
other_details: modified CYS 83
Source :
mol_id organism_scientific organism_common expression_system
1 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast Escherichia coli  (taxid:562)
gene: HIS7
mol_id organism_scientific organism_common expression_system
2 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast Escherichia coli  (taxid:562)
gene: HIS7
Authors : Chaudhuri, B.N., Smith, J.L.
Keywords : COMPLEX CYCLIZATION; IMIDAZOLE GLYCEROPHOSPHATE SYNTHASE, TRANSFERASE, LYASE
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

Towards Understanding the Mechanism of the Complex Cyclization Reaction Catalyzed by Imidazole Glycerophosphate Synthase: Crystal Structures of a Ternary Complex and the Free Enzyme

Chaudhuri, B.N.,Lange, C.,Myers, R.S.  et al.
(2003)  Biochemistry  42 : 7003 - 7012

PubMed: 12795595
DOI: 10.1021/bi034320h

Substrate-induced changes in the ammonia channel for imidazole glycerol phosphate synthase.

Myers, R.S.,Jensen, J.R.,Deras, I.L.  et al.
(2003)  Biochemistry  42 : 7013 - 7022

DOI: 10.1021/bi034314l

Reaction

Chain : B
UniProt : P33734 (HIS5_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5- phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5- amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D- erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate 4.3.2.10 -
-
H2O + L-glutamine = L-glutamate + NH4(+) 3.5.1.2 -
-