PDB ID: 1OUY
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Code | Name | Style | Show | Link | |
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094 | 1-(2,6-dichlorophenyl)-6-[(2,4-difluorophenyl)sulfanyl]-7-(1,2,3,6-tetrahydro-4-pyridinyl)-3,4-dihydropyrido[3,2-D]pyrimidin-2(1h)-one | PoSSuM |
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Download interaction data: 1OUY
Structure summary
Code : | 1OUY PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE | ||||||||||||
Title : | The structure of p38 alpha in complex with a dihydropyrido-pyrimidine inhibitor | ||||||||||||
Release Data : | 2003-09-02 | ||||||||||||
Compound : |
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Authors : | Fitzgerald, C.E., Patel, S.B., Becker, J.W., Cameron, P.M., Zaller, D., Pikounis, V.B., O'Keefe, S.J., Scapin, G. | ||||||||||||
Keywords : | MAP kinase, hydrophobic pocket, kinase domain, ATP binding domain, TRANSFERASE | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.5 Å ) | ||||||||||||
Citation : |
Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity
Fitzgerald, C.E.,Patel, S.B.,Becker, J.W.
et al.
PubMed: 12897767 p38MAP kinase inhibitors part 1: Design and development of a new class of potent and highly selective inhibitors based on 3,4-dihydropyrido[3,2-d]pyrimidone scaffold
Natarajan, S.R.,Wisnoski, D.D.,Singh, S.B.
et al.
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Reaction
Chain : | A | |||||||||||||
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UniProt : | Q16539 (MK14_HUMAN) | |||||||||||||
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