PDB ID: 1OUK
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Code | Name | Style | Show | Link | |
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084 | 4-[5-[2-(1-phenyl-ethylamino)-pyrimidin-4-yl]-1-methyl-4-(3-trifluoromethylphenyl)-1h-imidazol-2-yl]-piperidine | PoSSuM | |||
SO4 | Sulfate ion | PoSSuM |
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Download interaction data: 1OUK
Structure summary
Code : | 1OUK PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE | ||||||||||||
Title : | The structure of p38 alpha in complex with a pyridinylimidazole inhibitor | ||||||||||||
Release Data : | 2003-09-02 | ||||||||||||
Compound : |
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Source : |
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Authors : | Fitzgerald, C.E., Patel, S.B., Becker, J.W., Cameron, P.M., Zaller, D., Pikounis, V.B., O'Keefe, S.J., Scapin, G. | ||||||||||||
Keywords : | MAP kinase, hydrophobic pocket, Kinase domain, ATP binding domain, TRANSFERASE | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.5 Å ) | ||||||||||||
Citation : |
Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity
Fitzgerald, C.E.,Patel, S.B.,Becker, J.W.
et al.
PubMed: 12897767 Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase
Liverton, N.J.,Butcher, J.W.,Claiborne, C.F.
et al.
DOI: 10.1021/jm9805236 |
Reaction
Chain : | A | |||||||||||||
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UniProt : | Q16539 (MK14_HUMAN) | |||||||||||||
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