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Ligands
Code Name Style Show Link
CHC 6-ethyl-chenodeoxycholic acid
Non-standard Residues
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Glycosylation
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Code : 1OT7   PDBj   RCSB PDB   PDBe
Header : HORMONE/GROWTH FACTOR RECEPTOR
Title : Structural Basis for 3-deoxy-CDCA Binding and Activation of FXR
Release Data : 2004-03-23
Compound :
mol_id molecule chains synonym
1 Bile Acid Receptor A,B FXR; Farnesoid X-activated receptor; Farnesol receptor HRR-1; Retinoid X receptor-interacting protein 14; RXR-interacting protein 14
fragment: ligand binding domain
mol_id molecule chains
2 dodecamer peptide fragment of RPGR-interacting protein 1 C,D,E
fragment: GRIP1 NID3
Source :
mol_id organism_scientific organism_common expression_system
1 Rattus norvegicus  (taxid:10116) Norway rat Escherichia coli BL21(DE3)  (taxid:469008)
gene: NR1H4
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET-16b
mol_id organism_scientific
2
synthetic: yes
other_details: This sequence occurs naturally in humans
Authors : Mi, L.Z., Devarakonda, S., Harp, J.M., Han, Q., Pellicciari, R., Willson, T.M., Khorasanizadeh, S., Rastinejad, F.
Keywords : BILE ACID, NUCLEAR RECEPTOR, COACTIVATOR, LIGAND BINDING DOMAIN, FXR, HORMONE-GROWTH FACTOR RECEPTOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.90 Å )
Citation :

Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR

Mi, L.Z.,Devarakonda, S.,Harp, J.M.  et al.
(2003)  Mol.Cell  11 : 1093 - 1100

PubMed: 12718893
DOI: 10.1016/S1097-2765(03)00112-6

Chain : A, B
UniProt : Q62735 (NR1H4_RAT)
Reaction : -