Het-PDB Navi2 (PDB: 1OSV)

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Ligands
Code	Name		Style	Show	Link
CHC	6-ethyl-chenodeoxycholic acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1OSV

Code :

1OSV PDBj RCSB PDB PDBe

Header :

DNA BINDING PROTEIN

Title :

STRUCTURAL BASIS FOR BILE ACID BINDING AND ACTIVATION OF THE NUCLEAR RECEPTOR FXR

Release Data :

2004-03-23

Compound :

mol_id	molecule	chains	synonym
1	Bile acid receptor	A,B	Farnesoid X-activated receptor, Farnesol receptor HRR-1, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14
	fragment: ligand binding domain (FXR-LBD)

mol_id	molecule	chains	synonym
2	Nuclear receptor coactivator 2	C,D,E	NCoA-2, Transcription intermediary factor 2, Glucocorticoid receptor-interacting protein 1, GRIP-1
	fragment: Residues (741-752)

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Rattus norvegicus (taxid:10116)	Norway rat	Escherichia coli BL21(DE3) (taxid:469008)
	expression_system_strain: BL21(DE3) expression_system_vector_type: PLASMID expression_system_plasmid: pET16b

mol_id	organism_scientific
2
	synthetic: yes other_details: The coactivator peptide was synthesized. The sequence of the GRIP is naturally found in Rattus Norvegicus (Norway Rat).

Authors :

Mi, L.Z., Devarakonda, S., Harp, J.M., Han, Q., Pellicciari, R., Willson, T.M., Khorasanizadeh, S., Rastinejad, F.

Keywords :

LBD, bile acid, coactivator, nuclear receptor, DNA BINDING PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 2.50 Å )

Citation :

Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR

Mi, L.Z.,Devarakonda, S.,Harp, J.M. et al.
(2003) Mol.Cell 11 : 1093 - 1100

PDB ID: 1OSV