Brand  (β version)

PDB ID: 1OSH

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Ligands
Code Name Style Show Link
FEX Methyl 3-{3-[(cyclohexylcarbonyl){[4'-(dimethylamino)biphenyl-4-yl]methyl}amino]phenyl}acrylate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1OSH   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : A Chemical, Genetic, and Structural Analysis of the nuclear bile acid receptor FXR
Release Data : 2003-09-23
Compound :
mol_id molecule chains synonym
1 Bile acid receptor A Farnesoid X-activated receptor, Farnesol receptor HRR-1, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14
fragment: Ligand Binding Domain
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: NR1H4
expression_system_strain: BL21 (DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: pHIS8-3
Authors : Downes, M., Verdecia, M.A., Roecker, A.J., Hughes, R., Hogenesch, J.B., Kast-Woelbern, H.R., Bowman, M.E., Ferrer, J.-L., Anisfeld, A.M., Edwards, P.A., Rosenfeld, J.M., Alvarez, J.G.A., Noel, J.P., Nicolaou, K.C., Evans, R.M.
Keywords : Nuclear Receptor, Ligand Binding Domain, TRANSCRIPTION
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR

Downes, M.,Verdecia, M.A.,Roecker, A.J.  et al.
(2003)  Mol.Cell  11 : 1079 - 1092

PubMed: 12718892
DOI: 10.1016/S1097-2765(03)00104-7

Reaction

Chain : A
UniProt : Q96RI1 (NR1H4_HUMAN)
Reaction : -