Het-PDB Navi2 (PDB: 1ONZ)

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Ligands
Code	Name		Style	Show	Link
968	2-[(7-hydroxy-naphthalen-1-yl)-oxalyl-amino]-benzoic acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1ONZ

Code :

1ONZ PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Oxalyl-aryl-Amino Benzoic acid Inhibitors of PTP1B, compound 8b

Release Data :

2003-05-20

Compound :

mol_id	molecule	chains	synonym
1	Protein-tyrosine phosphatase, non-receptor type 1	A	Protein-tyrosine phosphatase 1B, PTP-1B
	ec: 3.1.3.48 fragment: PTP1B Catalytic Domain

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: PTPN1 OR PTP1B expression_system_strain: BL21(D33)pTPASE 1B expression_system_vector_type: plasmid expression_system_plasmid: pT7-7

Authors :

Liu, G., Szczepankiewicz, B.G., Pei, Z., Janowich, D.A., Xin, Z., Hadjuk, P.J., Abad-Zapatero, C., Liang, H., Hutchins, C.W., Fesik, S.W., Ballaron, S.J., Stashko, M.A., Lubben, T., Mika, A.K., Zinker, B.A., Trevillyan, J.M., Jirousek, M.R.

Keywords :

Protein Tyrosine Phosphatase, oxalyl-aryl-benzoic acid compound with napthyl moiety anchor inhibitor, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 2.40 Å )

Citation :

Discovery and Structure-Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B

Liu, G.,Szczepankiewicz, B.G.,Pei, Z. et al.
(2003) J.Med.Chem. 46 : 2093 - 2103

PubMed: 12747781
DOI: 10.1021/jm0205696

Potent, Selective Inhibitors of Protein Tyrosine Phosphatase 1B

Xin, Z.,Oost, T.K.,Abad-Zapatero, C. et al.
(2003) BIOORG.MED.CHEM.LETT. 13 : 1887 - 1890

DOI: 10.1016/S0960-894X(03)00302-0

Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy

Szczepankiewicz, B.G.,Liu, G.,Hajduk, P.J. et al.
(2003) J.Am.Chem.Soc. 125 : 4087 - 4096

DOI: 10.1021/ja0296733

Chain :

UniProt :

P18031 (PTN1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate	3.1.3.48	PROSITE- ProRule:PRU10044
	-	PROSITE- ProRule:PRU10044

PDB ID: 1ONZ

Hetero Atom Contents

Structure summary

Reaction