Brand  (β version)

PDB ID: 1ONP

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
FOM 3-[formyl(hydroxy)amino]propylphosphonic acid PoSSuM
MN Manganese (II) ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 1ONP   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : IspC complex with Mn2+ and fosmidomycin
Release Data : 2003-03-18
Compound :
mol_id molecule chains synonym
1 1-deoxy-D-xylulose 5-phosphate reductoisomerase A,B 2-C-Methyl-D-erythritol 4-phosphate synthase, IspC
ec: 1.1.1.267
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
expression_system_vector_type: plasmid
expression_system_plasmid: pQE30
Authors : Steinbacher, S., Kaiser, J., Eisenreich, W., Huber, R., Bacher, A., Rohdich, F.
Keywords : isoprenoid biosynthesis, mevalonate-independent pathway, IspC, oxidoreductase
Exp. method : X-RAY DIFFRACTION ( 2.5 Å )
Citation :

Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development.

Steinbacher, S.,Kaiser, J.,Eisenreich, W.  et al.
(2003)  J.BIOL.CHEM.  278 : 18401 - 18407

PubMed: 12621040
DOI: 10.1074/jbc.M300993200

Reaction

Chain : A, B
UniProt : P45568 (DXR_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D- xylulose 5-phosphate + H(+) + NADPH 1.1.1.267 PubMed:10631325, PubMed:10787409, PubMed:9707569
right-to-left