Het-PDB Navi2 (PDB: 1ONG)

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Ligands
Code	Name		Style	Show	Link
MA4	Cyclohexyl-hexyl-beta-D-maltoside				PoSSuM
WY4	7-(5,6-dihydro-8h-imidazo[2,1-C][1,4]oxazin-2-yl)-6-formyl-2,7-dihydro- [1,4]thiazepine-3-carboxylic acid				PoSSuM

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Download interaction data: 1ONG

Code :

1ONG PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

SHV-1 beta-lactamase with a penem inhibitor

Release Data :

2003-12-09

Compound :

mol_id	molecule	chains	synonym
1	BETA-LACTAMASE SHV-1	A	PIT-2; PENICILLINASE
	ec: 3.5.2.6

Source :

mol_id	organism_scientific	expression_system
1	Klebsiella pneumoniae (taxid:573)	Escherichia coli str. K-12 substr. DH10B (taxid:316385)
	strain: 15571 gene: BLA expression_system_strain: DH10B expression_system_vector_type: PLASMID expression_system_plasmid: PBCSK expression_system_gene: BLA

Authors :

Nukaga, M., Mayama, K., Bonomo, R.A., Knox, J.R.

Keywords :

BETA-LACTAM HYDROLASE, PENICILLINASE, DETERGENT BINDING, DRUG DESIGN, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 1.10 Å )

Citation :

Inhibition of Class A and Class C Beta-Lactamases by Penems: Crystallographic Structures of a Novel 1,4-Thiazepine Intermediate

Nukaga, M.,Abe, T.,Venkatesan, A.M. et al.
(2003) Biochemistry 42 : 13152 - 13159

Chain :

UniProt :

P14557 (BLA1_KLEPN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a beta-lactam + H2O = a substituted beta-amino acid	3.5.2.6	PROSITE- ProRule:PRU10101
a beta-lactam + H2O = a substituted beta-amino acid	-	PROSITE- ProRule:PRU10101

PDB ID: 1ONG