Het-PDB Navi2 (PDB: 1OMW)

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Ligands
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Non-standard Residues
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CMT	O-methylcysteine

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Download interaction data: 1OMW

Code :

1OMW PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal Structure of the complex between G Protein-Coupled Receptor Kinase 2 and Heterotrimeric G Protein beta 1 and gamma 2 subunits

Release Data :

2003-06-03

Compound :

mol_id	molecule	chains	synonym
1	G-protein coupled receptor kinase 2	A	GRK2, Beta-ARK-1, Beta-adrenergic receptor kinase 1
	ec: 2.7.1.126 mutation: S670A

mol_id	molecule	chains	synonym
2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 1	B	Transducin beta chain 1

mol_id	molecule	chains	synonym
3	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	G	G gamma-I

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Bos taurus (taxid:9913)	Cattle	Spodoptera frugiperda (taxid:7108)
	gene: GRK2 expression_system_common: Fall armyworm expression_system_strain: Sf9 expression_system_vector_type: Baculovirus

mol_id	organism_scientific	organism_common	expression_system
2	Bos taurus (taxid:9913)	Cattle	Spodoptera frugiperda (taxid:7108)
	gene: GNB1 expression_system_common: Fall armyworm expression_system_strain: SF9 expression_system_vector_type: Baculovirus

mol_id	organism_scientific	organism_common	expression_system
3	Bos taurus (taxid:9913)	Cattle	Spodoptera frugiperda (taxid:7108)
	gene: GNG2 expression_system_common: Fall armyworm expression_system_strain: Sf9 expression_system_vector_type: Baculovirus

Authors :

Lodowski, D.T., Pitcher, J.A., Capel, W.D., Lefkowitz, R.J., Tesmer, J.J.G.

Keywords :

WD-40 repeat, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.50 Å )

Citation :

Keeping G proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and G-Beta-Gamma

Lodowski, D.T.,Pitcher, J.A.,Capel, W.D. et al.
(2003) Science 300 : 1256 - 1262

Chain :

UniProt :

P21146 (ARBK1_BOVIN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
[beta-adrenergic receptor] + ATP = [beta-adrenergic receptor]- phosphate + ADP + H(+)	2.7.11.15	UniProtKB:P26817
	left-to-right	UniProtKB:P26817

PDB ID: 1OMW