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Ligands
Code Name Style Show Link
Non-standard Residues
Code Name Show
BB9 (2z)-2-amino-3-sulfanylprop-2-enoic acid
DBU (2z)-2-aminobut-2-enoic acid
DCY D-cysteine
DHA 2-amino-acrylic acid
MH6 3-hydroxy-2-iminopropanoic acid
TS9 (2s,3s,4r)-2-amino-3,4-dihydroxy-3-methylpentanoic acid
Glycosylation
Code Name Emphasize
Modification
Code Name Show
NH2 Amino group
QUA 8-hydroxy-4-(1-hydroxyethyl)quinoline-2-carboxylic acid
Code : 1OLN   PDBj   RCSB PDB   PDBe
Header : RIBOSOME/ANTIBIOTIC
Title : Model for thiostrepton antibiotic binding to L11 substrate from 50S ribosomal RNA
Release Data : 2003-09-11
Compound :
mol_id molecule chains
1 50S RIBOSOMAL PROTEIN L11 A
mol_id molecule chains synonym
2 THIOSTREPTON B ALANINAMIDE, BRYAMYCIN, THIACTIN
mol_id molecule chains
3 RNA C
fragment: RESIDUES 1051-1108
Source :
mol_id organism_scientific
1 THERMOTOGA MARITIMA  (taxid:2336)
mol_id organism_scientific
2 STREPTOMYCES AZUREUS  (taxid:146537)
mol_id organism_scientific
3 THERMOTOGA MARITIMA  (taxid:2336)
Authors : Lentzen, G., Klinck, R., Matassova, N., Aboul-Ela, F., Murchie, A.I.H.
Keywords : RIBOSOME-ANTIBIOTIC COMPLEX, THIOPEPTIDE, ANTIBACTERIAL, THIAZOLE, OXAZOLE, RIBOSOME, L11, TRANSLATION INHIBITION
Exp. method : SOLUTION NMR
Citation :

Structural Basis for Contrasting Activities of Ribosome Binding Thiazole Antibiotics

Lentzen, G.,Klinck, R.,Matassova, N.  et al.
(2003)  Chem.Biol.  10 : 769

PubMed: 12954336
DOI: 10.1016/S1074-5521(03)00173-X

A Detailed View of a Ribosomal Active Site: The Structure of the L11-RNA Complex

Wimberly, B.T.,Guymon, R.,Mccutcheon, J.P.  et al.
(1999)  Cell(Cambridge,Mass.)  97 : 491

PubMed: 10338213
DOI: 10.1016/S0092-8674(00)80759-X

Crystal Structure of a Conserved Ribosomal Protein-RNA Complex

Conn, G.L.,Draper, D.E.,Lattman, E.E.  et al.
(1999)  Science  284 : 1171

PubMed: 10325228
DOI: 10.1126/SCIENCE.284.5417.1171

Chain : A
UniProt : P29395 (RL11_THEMA)
Reaction : -
Chain : B
UniProt : P0C8P8 (THCL_STRAJ)
Reaction : -